The British Journal of Rheumatology, Vol 36, 637-642, Copyright © 1997 by British Society for Rheumatology
M Takahashi, M Suzuki, K Kushida, S Miyamoto and T Inoue
Pentosidine is one of the advanced glycation end-products and is formed by
glycosylation and oxidation. The aim of this study is to investigate the
relationship between serum and urinary pentosidine levels and the activity
of rheumatoid arthritis (RA). Using HPLC with column switching, we measured
pentosidine in serum and urine from 77 patients with RA and 62 normal
control subjects. The clinical features, blood biochemistry and activity of
inflammation were examined in RA patients. Serum and urinary pentosidine in
RA were significantly higher than in controls. Pentosidine significantly
correlated with age, C-reactive protein (CRP), erythrocyte sedimentation
rate (ESR), rheumatoid factor, joint score and Lansbury Index in RA. The
levels of pentosidine were higher in patients with active RA than in those
with inactive RA. Serum and urine levels of pentosidine correlated with the
activity of RA, and serum and urinary pentosidine may be a significant and
novel marker for evaluating the disease status and the activity of RA.
ORIGINAL PAPERS
Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis
Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Japan.
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