The British Journal of Rheumatology, Vol 36, 855-860, Copyright © 1997 by British Society for Rheumatology
HH Kuper, MA van Leeuwen, PL van Riel, ML Prevoo, PM Houtman, WF Lolkema and MH van Rijswijk
An assessment of the onset of radiographic damage in the large joints (hip,
knees, shoulders, elbows, ankles and tarsus) in patients with early
rheumatoid arthritis, and the relationship of the progression of large
joint damage with joint damage in hands and feet, with physical disability,
and with cumulative disease activity, was performed in a prospective 6 yr
follow-up study. Large joint damage appeared to be an early phenomenon with
20% of the patients having some damage in at least one large joint within 1
yr, and 50% of the patients within 6 yr after disease onset. Radiographic
damage in large joints was significantly related to the damage in hands and
feet, the physical disability index, and the cumulative disease activity.
The initial disease activity at study entry was the only prognostic factor
that reached significance.
ORIGINAL PAPERS
Radiographic damage in large joints in early rheumatoid arthritis: relationship with radiographic damage in hands and feet, disease activity, and physical disability
Department of Rheumatology, University Hospital Groningen, The Netherlands.
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