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The British Journal of Rheumatology, Vol 36, 1012-1015, Copyright © 1997 by British Society for Rheumatology

ORIGINAL PAPERS

Sesame oil in injectable gold: two drugs in one?

S ten Wolde, F Engels, AM Miltenburg, EA Kuijpers, GI Struijk-Wielinga and BA Dijkmans
Department of Rheumatology, University Hospital Leiden, The Netherlands.

To investigate the potential anti-inflammatory effects of sesame oil, which is present in the injectable gold preparation Auromyose, the synthesis of tumour necrosis factor alpha (TNF-alpha), prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) by in vitro stimulated blood cells was measured before, during and after 12 weeks of dietary supplementation with 18 g of sesame oil daily in 11 healthy male volunteers. Neither TNF-alpha, PGE2 nor LTB4 production levels showed statistically significant changes during the 12 weeks of dietary supplementation with sesame oil. These results do not suggest an anti-inflammatory effect of sesame oil as present in injectable gold preparations which are used in the treatment of rheumatoid arthritis.
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