The British Journal of Rheumatology, Vol 37, 46-50, Copyright © 1998 by British Society for Rheumatology
IF Petersson, T Boegard, B Svensson, D Heinegard and T Saxne
Serum concentrations of two extracellular matrix molecules were determined
over a 3 yr period in individuals with chronic knee pain to investigate
whether sequential serum measurements of cartilage- and bone-derived
molecular fragments reflect early stages of osteoarthritis (OA) of the knee
joints. Thirty-eight individuals with chronic knee pain (> 3 months at
inclusion) with or without radiographic evidence of knee joint OA at the 3
yr follow-up radiographic examination were studied. Serum concentrations of
cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP)
increased significantly (P < 0.001) in the 23 individuals with
radiographic OA at follow-up, while remaining unchanged in the 15
individuals with normal radiographs at follow-up. The baseline
concentrations of the two variables did not differ between the groups.
These findings suggest that pathological processes in cartilage and
subchondral bone coincide in OA, and appear to be reflected by circulating
levels of macromolecules released from cartilage and bone. Changes in serum
levels of COMP and BSP are potential tools in studies of knee joint OA in
subjects with chronic knee pain.
ORIGINAL PAPERS
Changes in cartilage and bone metabolism identified by serum markers in early osteoarthritis of the knee joint
Spenshult's Hospital for Rheumatic Diseases, Oskarstrom, Sweden.
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