The British Journal of Rheumatology, Vol 37, 64-70, Copyright © 1998 by British Society for Rheumatology
LC Tetlow and DE Woolley
The degradation of fibrillar type II collagen is a major feature of
cartilage destruction in rheumatoid arthritis (RA). Since collagenase 3 is
produced by chondrocytes and preferentially degrades type II cartilage
collagen, it seemed likely that this enzyme would have a prominent role in
the destruction of rheumatoid joints. Using immunolocalization techniques,
we have examined and compared the production and distributions of
collagenase 1 and collagenase 3 in cells and tissues derived from
rheumatoid knee arthroplasties. Primary cultures of chondrocytes stimulated
with interleukin-1 beta showed that most of the cells produced collagenase
1, whereas only a minority (approximately 5-10%) produced collagenase 3; a
few chondrocytes demonstrated the co-ordinate production of both enzymes.
Primary cultures of rheumatoid synoviocytes produced collagenase 1, but not
collagenase 3. Both enzymes were demonstrated in the rheumatoid lesion.
Collagenase 1 was more commonly observed in both synovium and cartilage (22
of the 28 specimens), was especially prominent at cartilage erosion sites,
and most of the positive specimens demonstrated extracellular enzyme. By
contrast, collagenase 3 was observed less frequently (7/28 specimens) and
was produced by relatively few chondrocytes and synovial cells, this
usually being much less than that observed for chondrocytes of
osteoarthritic cartilage. These observations suggest different regulatory
mechanisms for the production of collagenases 1 and 3 in the rheumatoid
lesion, and demonstrate that the distribution and production of collagenase
1 are far more prevalent than those for collagenase 3.
ORIGINAL PAPERS
Comparative immunolocalization studies of collagenase 1 and collagenase 3 production in the rheumatoid lesion, and by human chondrocytes and synoviocytes in vitro
University Department of Medicine, Manchester Royal Infirmary.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. J. Litherland, C. Dixon, R. L. Lakey, T. Robson, D. Jones, D. A. Young, T. E. Cawston, and A. D. Rowan Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent J. Biol. Chem., May 23, 2008; 283(21): 14221 - 14229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Catterall, A. D. Rowan, S. Sarsfield, J. Saklatvala, R. Wait, and T. E. Cawston Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M Rheumatology, September 1, 2006; 45(9): 1101 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Shingleton, D. Jones, X. Xu, T. E. Cawston, and A. D. Rowan Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes Rheumatology, August 1, 2006; 45(8): 958 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Aggarwal, S Panda, and R Misra Effect of etanercept on matrix metalloproteinases and angiogenic vascular endothelial growth factor: a time kinetic study Ann Rheum Dis, July 1, 2004; 63(7): 891 - 892. [Full Text]
|
|
|
|
 |
|
 A. D. Rowan, W. Hui, T. E. Cawston, and C. D. Richards Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model Am. J. Pathol., June 1, 2003; 162(6): 1975 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P J Koshy, N Henderson, C Logan, P F Life, T E Cawston, and A D Rowan Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines Ann Rheum Dis, August 1, 2002; 61(8): 704 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L C Tetlow and D E Woolley Histamine stimulates matrix metalloproteinase-3 and -13 production by human articular chondrocytes in vitro Ann Rheum Dis, August 1, 2002; 61(8): 737 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P K Petrow, D Wernicke, C Schulze Westhoff, K M Hummel, R Brauer, J Kriegsmann, E Gromnica-Ihle, R E Gay, and S Gay Characterisation of the cell type-specificity of collagenase 3 mRNA expression in comparison with membrane type 1 matrix metalloproteinase and gelatinase A in the synovial membrane in rheumatoid arthritis Ann Rheum Dis, May 1, 2002; 61(5): 391 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Katrib, P. P. Tak, J. V. Bertouch, C. Cuello, H. P. McNeil, T. J. M. Smeets, M. C. Kraan, and P. P. Youssef Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis Rheumatology, September 1, 2001; 40(9): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Hembry, J. Dyce, I. Driesang, E. B. Hunziker, A. J. Fosang, J. A. Tyler, and G. Murphy Immunolocalization of Matrix Metalloproteinases in Partial-Thickness Defects in Pig Articular Cartilage : A Preliminary Report J. Bone Joint Surg. Am., June 1, 2001; 83(6): 826 - 838. [Abstract] [Full Text]
|
|
|
|
 |
|
 W. Q. Li, F. Dehnade, and M. Zafarullah Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes Requires Janus Kinase/STAT Signaling Pathway J. Immunol., March 1, 2001; 166(5): 3491 - 3498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W Hui, A D Rowan, and T Cawston Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1{alpha} Ann Rheum Dis, March 1, 2001; 60(3): 254 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wong, C. Cuello, J. V. Bertouch, P. J. Roberts-Thomson, M. J. Ahern, M. D. Smith, and P. P. Youssef The effects of pulse methylprednisolone on matrix metalloproteinase and tissue inhibitor of metalloproteinase-1 expression in rheumatoid arthritis Rheumatology, October 1, 2000; 39(10): 1067 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cavallo, L. Sabadini, L. Rollo, M. Catenaccio, S. Lorenzini, N. Pipitone, R. Marcolongo, and T. Yamamoto Nitric oxide synthesis in peripheral blood mononuclear and polymorphonuclear cells from patients with systemic sclerosis Rheumatology, December 1, 1999; 38(12): 1301 - 1304. [Full Text] [PDF]
|
|