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The British Journal of Rheumatology, Vol 37, 1132-1134, Copyright © 1998 by British Society for Rheumatology

ORIGINAL PAPERS

Neuropsychiatric systemic lupus erythematosus and the syndrome of inappropriate secretion of antidiuretic hormone: a case report with very late onset systemic lupus erythematosus

SM Mirsattari, C Power, A Fine, GS McGinn, S Ludwick and JM Canvin
Department of Internal Medicine, University of Manitoba Health Sciences Centre, Winnipeg, Canada.

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with neuropsychiatric lupus (NP-SLE) is rare. We report a case of SIADH associated with the new onset of SLE in an 88-yr-old female. The unique features of this case include the extreme age of onset of SLE presenting with neuropsychiatric manifestations and positive antiribosomal P antibody titres. Both the NP manifestations of SLE and SIADH were highly correlated with the SLE disease activity. This case illustrates a novel presentation of NP-SLE with SIADH which may develop due to antibody-mediated hypothalamic dysfunction.
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