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The British Journal of Rheumatology, Vol 37, 1188-1192, Copyright © 1998 by British Society for Rheumatology

ORIGINAL PAPERS

Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis

H Ihn, S Sato, M Fujimoto, K Takehara and K Tamaki
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.

OBJECTIVE: To determine the serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) in patients with systemic sclerosis (SSc). METHOD: Serum samples from 80 patients with SSc and 20 healthy control subjects were examined by a sensitive enzyme-linked immunosorbent assay. RESULTS: The serum levels of sVCAM-1 and sE-selectin were significantly higher in the patients with SSc than in the healthy controls. The serum levels of sVCAM-1 were correlated with the presence of pulmonary fibrosis, joint involvement and elevated erythrocyte sedimentation rate levels. The serum levels of sE-selectin were correlated with the presence of pulmonary fibrosis. CONCLUSION: These results suggest that endothelial activation is involved in the development of this disease.
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