The British Journal of Rheumatology, Vol 37, 1198-1202, Copyright © 1998 by British Society for Rheumatology
EM Dennison, NK Arden, S Kellingray, P Croft, D Coggon and C Cooper
BACKGROUND: Recent epidemiological studies suggest that post-menopausal
hormone replacement therapy might reduce the risk of hip osteoarthritis
(OA) in women. However, the association of the disorder with other
reproductive variables is controversial. We addressed this issue in a
population-based case control study among 413 female cases and 413 age- and
sex-matched controls. METHODS: A total of 413 women listed for hip
replacement because of primary OA over an 18 month period were compared
with an equal number of controls selected from the general population and
individually matched for age and general practice. Information about
reproductive variables was obtained by questionnaire administered at
interview. RESULTS: The risk of hip OA was significantly elevated among
women who had had an oophorectomy (OR = 1.9, 95% CI 1.0-3.7). After
adjustment for body mass index, the presence of Heberden's nodes, previous
hip injury and past leisure sporting activity (all independent risk factors
for hip OA), and for other reproductive variables, there was a
non-significant, protective effect of long-term hormone replacement
therapy, such that > or =5 yr of use was associated with a 40% reduction
in risk (OR = 0.6, 95% CI 0.2-1.8). Paradoxically, short- term HRT use (up
to 5 yr duration) was associated with an excess risk of hip OA (OR = 1.7,
95% CI 0.9-3.3). There was no association between the risk of hip OA and
use of oral contraceptives, parity or hysterectomy. CONCLUSIONS: These data
are consistent with previous studies suggesting a protective effect of
long-term hormone replacement therapy on the risk of hip OA. By contrast,
an elevation of risk in short-term users was demonstrated. Our results also
suggest that risk is increased among women who have undergone unilateral or
bilateral oophorectomy. Studies are required to investigate the mechanisms
underlying these associations.
ORIGINAL PAPERS
Hormone replacement therapy, other reproductive variables and symptomatic hip osteoarthritis in elderly white women: a case-control study
MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  B. M. de Klerk, D. Schiphof, F. P. M. J. Groeneveld, B. W. Koes, G. J. V. M van Osch, J. B. J. van Meurs, and S. M. A. Bierma-Zeinstra No clear association between female hormonal aspects and osteoarthritis of the hand, hip and knee: a systematic review Rheumatology, September 1, 2009; 48(9): 1160 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B Liu, A Balkwill, C Cooper, A Roddam, A Brown, V Beral, and on behalf of the Million Women Study Collaborators Reproductive history, hormonal factors and the incidence of hip and knee replacement for osteoarthritis in middle-aged women Ann Rheum Dis, July 1, 2009; 68(7): 1165 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. de Klerk, D. Schiphof, F. P. M. J. Groeneveld, B. W. Koes, G. J. V. M. van Osch, J. B. J. van Meurs, and S. M. A. Bierma-Zeinstra Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip: a systematic review Rheumatology, February 1, 2009; 48(2): 104 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tzagarakis-Foster, R. Geleziunas, A. Lomri, J. An, and D. C. Leitman Estradiol Represses Human T-cell Leukemia Virus Type 1 Tax Activation of Tumor Necrosis Factor-alpha Gene Transcription J. Biol. Chem., November 15, 2002; 277(47): 44772 - 44777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A E Wluka, S R Davis, M Bailey, S L Stuckey, and F M Cicuttini Users of oestrogen replacement therapy have more knee cartilage than non-users Ann Rheum Dis, April 1, 2001; 60(4): 332 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy Can. Med. Assoc. J., May 1, 2000; 162(10): 1421 - 1424.
|
|
|
|
|
|
Z. Mustafa, K. Chapman, C. Irven, A. J. Carr, K. Clipsham, J. Chitnavis, J. S. Sinsheimer, V. A. Bloomfield, M. McCartney, O. Cox, et al. Linkage analysis of candidate genes as susceptibility loci for osteoarthritis--suggestive linkage of COL9A1 to female hip osteoarthritis Rheumatology, March 1, 2000; 39(3): 299 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Erb, H. Brenner, K.-P. Günther, and T. Stürmer Hormone replacement therapy and patterns of osteoarthritis: baseline data from the Ulm Osteoarthritis Study Ann Rheum Dis, February 1, 2000; 59(2): 105 - 109. [Abstract] [Full Text]
|
|