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The British Journal of Rheumatology, Vol 37, 1203-1206, Copyright © 1998 by British Society for Rheumatology

ORIGINAL PAPERS

Tumour necrosis factor microsatellites in reactive arthritis

J Tuokko, S Koskinen, P Westman, U Yli-Kerttula, A Toivanen and J Ilonen
Turku Immunology Centre and Department of Medical Microbiology, University of Turku, Finland.

The purpose was to study tumour necrosis factor (TNF)-a, -b and -c microsatellites as potential new susceptibility markers for reactive arthritis (ReA). Fifty-nine patients typed for HLA-B27 were studied for frequencies of TNF microsatellite alleles and compared with allele frequencies determined from 285 random haplotypes and 46 healthy HLA- B27-positive controls. TNFa, -b and -c microsatellite sequences were amplified by the polymerase chain reaction, and the size of the product was defined by an automated sequencer. The frequencies of TNFa6 and -c1 alleles were found to be increased in patients with ReA, whereas TNFa11 and -c2 frequencies were decreased as compared to control haplotypes. The increase in the c1 allele in patients with ReA independently from HLA-B27 suggests that it might be a new susceptibility marker for the disease. The association of ReA with other alleles was due to a linkage disequilibrium with HLA-B27.
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