The British Journal of Rheumatology, Vol 37, 1229-1232, Copyright © 1998 by British Society for Rheumatology
ML Bertolaccini, B Roch, O Amengual, T Atsumi, MA Khamashta and GR Hughes
The family of antiphospholipid antibodies (aPL) includes a heterogeneous
population of autoantibodies whose specificity is directed against not only
phospholipids, but their complex with plasma proteins. Anticardiolipin
antibodies (aCL) and lupus anticoagulant (LA) tests are widely performed to
screen the aPL family which is associated with thrombotic complications in
patients with systemic lupus erythematosus (SLE) or antiphospholipid
syndrome (APS). The clinical significance of other aPL tests, including
antibodies against phosphatidylserine (aPS), phosphatidylinositol (aPI),
phosphatidic acid (aPA), phosphatidylcholine (aPC) and
phosphatidylethanolamine (aPE), has not been established. The purpose of
this study was to evaluate whether multiple aPL tests have enhanced
diagnostic value for APS. We tested IgG/M/A aPS, aPI, aPA, aPC and aPE by
ELISA using 10% bovine serum as blocking and sample diluent in 26 SLE
patients with clinical manifestations of APS, but negative for both aCL and
LA (Group 1). The results were compared with 32 SLE patients without any
features of APS (Group 2) and 24 SLE patients with APS (aCL and/or LA
positive) (Group 3). In Group 1, 1/26 (4%) was positive for IgA aPE, less
frequent than in other groups, and none of the patients had any other aPL.
In Group 2, 1/32 (3%) was positive for aPS, two (6%) for aPI, one (3%) for
aPA and four (12.5%) for aPE. None was positive for aPC. In the third
group, 13/24 (54%) were positive for aPS, 11 (46%) for aPI, 15 (63%) for
aPA, four (17%) for aPC and seven (29%) for aPE. Since aPE was found in
some patients, we extended the study, including 207 SLE patients, and
tested aPE. IgG/M/A aPE was found in six (3%), 10(5%) and 21 (10%),
respectively, but no association was found between aPE and any clinical
features of APS. This study suggests that screening by multiple aPL tests
does not increase the diagnostic yield in APS.
ORIGINAL PAPERS
Multiple antiphospholipid tests do not increase the diagnostic yield in antiphospholipid syndrome
Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. A. Ozturk, I. C. Haznedaroglu, M. Turgut, and H. Goker Current Debates in Antiphospholipid Syndrome: The Acquired Antibody-Mediated Thrombophilia Clinical and Applied Thrombosis/Hemostasis, April 1, 2004; 10(2): 89 - 126. [Abstract] [PDF]
|
|
|
|
 |
|
 G R V Hughes and M A Khamashta Seronegative antiphospholipid syndrome Ann Rheum Dis, December 1, 2003; 62(12): 1127 - 1127. [Full Text] [PDF]
|
|
|
|
 |
|
 D M Levy, M P Massicotte, E Harvey, D Hebert, and E D Silverman Thromboembolism in paediatric lupus patients Lupus, October 1, 2003; 12(10): 741 - 746. [Abstract] [PDF]
|
|
|
|
|
|
D Caccavo, F Del Porto, P Garzia, A P Mitterhofer, S Galluzzo, A Rigon, M Vadacca, M F Navajas, A Amoroso, and A Afeltra Raynaud's phenomenon and antiphospholipid antibodies in systemic lupus erythematosus: is there an association? Ann Rheum Dis, October 1, 2003; 62(10): 1003 - 1005. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. W. Branch and M. A. Khamashta Antiphospholipid Syndrome: Obstetric Diagnosis, Management, and Controversies Obstet. Gynecol., June 1, 2003; 101(6): 1333 - 1344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Wasmuth, D. Oliver y Minarro, A. Homrighausen, L. Leifeld, J. K. Rockstroh, T. Sauerbruch, and U. Spengler Phospholipid Autoantibodies and the Antiphospholipid Antibody Syndrome: Diagnostic Accuracy of 23 Methods Studied by Variation in ROC Curves with Number of Clinical Manifestations Clin. Chem., July 1, 2002; 48(7): 1004 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Radway-Bright, C. T. Ravirajan, and D. A. Isenberg The prevalence of antibodies to anionic phospholipids in patients with the primary antiphospholipid syndrome, systemic lupus erythematosus and their relatives and spouses Rheumatology, April 1, 2000; 39(4): 427 - 431. [Abstract] [Full Text] [PDF]
|
|