The British Journal of Rheumatology, Vol 37, 1334-1337, Copyright © 1998 by British Society for Rheumatology
S Lee, H Kaneko, I Sekigawa, Y Tokano, Y Takasaki and H Hashimoto
OBJECTIVE: To investigate the relationship between interleukin (IL)-16 and
systemic lupus erythematosus (SLE). METHODS: Serum levels of IL-16 were
examined in SLE patients using an enzyme-linked immunosorbent assay
(ELISA). RESULTS: The serum level of IL-16 in the patients was much higher
than that in healthy volunteers (P < 0.001). An increase in IL-16 was
observed in proportion to the activity of SLE assessed by the SLE Disease
Activity Index (SLEDAI) score (P < 0.0001). CONCLUSIONS: Our
observations suggest an interaction between disease activity and the
production of IL-16 in SLE, and reveal that IL-16 is a useful indicator of
disease activity. This is the first report describing the relationship
between IL-16 and SLE.
ORIGINAL PAPERS
Circulating interleukin-16 in systemic lupus erythematosus
Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Japan.
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