The British Journal of Rheumatology, Vol 37, 514-519, Copyright © 1998 by British Society for Rheumatology
Y Kipen, BJ Strauss and EF Morand
The objectives were to determine the body composition, and the effects of
disease and corticosteroid therapy on body composition, in a population of
female patients with systemic lupus erythematosus (SLE). All female SLE
patients managed through a single centre were invited to participate in a
cross-sectional study of body composition. Data were collected by
standardized interview and examination, and review of medical records. Body
composition was assessed by dual-energy X-ray absorptiometry (DXA).
Eighty-two subjects were evaluated, 30 of whom were post-menopausal.
Univariate linear regression analysis revealed a significant association of
reduced fat-free mass with SLE severity [as measured by the Systemic Lupus
International Collaborative Clinics (SLICC)] (P = 0.020), a history of
corticosteroid exposure (P = 0.043) and age (P = 0.048). Reduced total body
bone mineral density (BMD) was also significantly associated with SLICC (P
< 0.001) and corticosteroid exposure (P = 0.017), and with age (P <
0.001), post-menopausal status (P = 0.003) and the duration of menopause (P
< 0.001). Stepwise multiple linear regression analysis revealed a
significant association between fat-free mass and total body, lumbar spine
and femoral neck BMD (P = 0.007, P = 0.025, P = 0.003, respectively). Fat
mass was significantly associated only with lumbar spine BMD (P = 0.008).
In this SLE population, disease severity and corticosteroid exposure were
independently associated with a negative effect both on total body BMD and
on fat-free mass. Fat-free mass was a significant predictor of lumbar
spine, femoral neck and total body BMD.
ORIGINAL PAPERS
Body composition in systemic lupus erythematosus
Department of Rheumatology, Monash Medical Centre, Clayton, Melbourne, Australia.
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