The British Journal of Rheumatology, Vol 37, 520-524, Copyright © 1998 by British Society for Rheumatology
C Fendler, J Braun, U Eggens, S Laitko, H Sorensen, A Distler and J Sieper
The cellular immune response seems to be important for the pathogenesis of
reactive arthritis (ReA) and a bacteria-specific lymphocyte proliferation
(LP) is often found in synovial fluid (SF) of ReA patients. However, the
role of the bacteria-specific LP in peripheral blood (PB) is less well
defined. In this study, we investigated 215 paired samples of SF and PB
from patients with ReA (n = 65), undifferentiated oligoarthritis (n = 133)
and undifferentiated spondylarthropathy (n = 17) to analyse the LP in PB
and SF in relation to time. In 24 out of 87 patients (27.6%) with a
bacteria-specific LP in synovial fluid, a positive LP to the same bacterium
was also found in PB. While a positive LP in SF was found most frequently
in the first week of the arthritis, a positive LP in PB was detected in 45%
of patients when investigated between weeks 2 and 4 after the onset of
arthritis, but was rarely found very early and late in the course of the
arthritis. The time point seems to be crucial for the investigation of an
LP in PB in patients with ReA.
ORIGINAL PAPERS
Bacteria-specific lymphocyte proliferation in peripheral blood in reactive arthritis and related diseases
Deutsches Rheumaforschungszentrum, Department of Nephrology and Rheumatology, Klinikum Benjamin Franklin, Berlin, Germany.
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