The British Journal of Rheumatology, Vol 37, 525-531, Copyright © 1998 by British Society for Rheumatology
H Tiwana, RS Walmsley, C Wilson, JY Yiannakou, PJ Ciclitira, AJ Wakefield and A Ebringer
This study was carried out to characterize the antibody class response by
ELISA to seven Klebsiella pneumoniae serotypes (K2, K3, K17, K21, K26, K36,
K50) in five different groups, 40 HLA-B27-positive ankylosing spondylitis
(AS) patients, 46 patients with Crohn's disease (CD), 38 patients with
ulcerative colitis (UC), 50 patients with active anti- endomysial
antibody-positive coeliac disease and 40 healthy controls, using whole
bacteria and capsular polysaccharide. IgG antibody levels were
significantly elevated in AS patients to K17, K36, K50; IgA to K2, K3, K21,
K26, K36 and K50; and IgM to serotype K21 when compared to normal controls.
Furthermore, IgG antibody levels were significantly elevated in CD patients
to K2, K17, K21, K26, K36 and K50; IgA to K2, K3, K21, K26, K36 and K50;
and IgM to K2, K3, K17, K21 and K50. Increased IgG antibody levels in the
UC group were limited only to K17, K36 and K50. No antibody class was
increased to any of the K. pneumoniae serotypes in the coeliac disease
group. The immune responses in AS patients also involve Klebsiella bacteria
having capsular serotypes other than K26, K36 and K50. The similarity in
the immune responses between CD and AS groups suggests that many AS
patients may have occult bowel inflammation.
ORIGINAL PAPERS
Characterization of the humoral immune response to Klebsiella species in inflammatory bowel disease and ankylosing spondylitis
Division of Life Sciences, Infection and Immunity Group, King's College, London.
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