The British Journal of Rheumatology, Vol 37, 691-695, Copyright © 1998 by British Society for Rheumatology
T Kordossis, S Paikos, K Aroni, P Kitsanta, A Dimitrakopoulos, E Kavouklis, V Alevizou, P Kyriaki, FN Skopouli and HM Moutsopoulos
The aims of the study were (a) to investigate the prevalence of
Sjogren's-like syndrome (SLS) in an unselected population of HIV-1-
positive patients and (b) to describe the pathology and immunopathology of
the labial minor salivary gland biopsy. Seventy-seven HIV-1-positive
patients were asked to answer the validated questionnaire of the European
preliminary criteria for the classification of Sjogren's syndrome on oral
and ocular sicca symptoms. Twenty-six patients gave one positive answer to
both ocular and oral symptoms, and of these 14 (hepatitis C virus negative)
consented to participate in the study (patients group). Ten age- and
sex-matched HIV-1-positive patients with a negative questionnaire
constituted the control group. Patients and controls had: (a) Schirmer's
test and slit-lamp examination after Rose Bengal staining; (b) parotid
gland scanning with technetium; (c) detection of autoantibodies in sera to
Ro/SSA and La/SSB; (d) labial salivary gland biopsy (patients group only).
The control group gave negative parotid gland scanning and only one gave a
positive Rose Bengal staining test. In the patients group, parotid gland
enlargement was manifested by three patients and only one gave positive
Rose Bengal staining test. Six out of the 14 patients had biopsies
identical with Sjogren's syndrome and five of these gave positive parotid
gland scanning. In the biopsies of four other patients, mucoid degeneration
of the stroma was found. Immunopathology revealed that the predominant
cells were T cells with the CD8 phenotype. None of the patient and control
sera had autoantibodies to Ro/SSA and La/SSB, whereas all patients had
hypergammaglobulinaemia. The overall prevalence of possible SLS in a mixed
population of HIV(+) patients (88.3% men and 11.7% women) was 7.79% which
is >2.5 times higher than that observed in normal Greek adult females.
ORIGINAL PAPERS
Prevalence of Sjogren's-like syndrome in a cohort of HIV-1-positive patients: descriptive pathology and immunopathology
Department of Pathophysiology, Medical School, National University of Athens, Greece.
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