The British Journal of Rheumatology, Vol 37, 740-745, Copyright © 1998 by British Society for Rheumatology
CP Mavragani, UG Dafni, AG Tzioufas and HM Moutsopoulos
OBJECTIVE: In the present retrospective cohort study, the association of
anti-Ro/SSA antibody with pregnancy loss and adverse pregnancy outcome in
women with autoimmune diseases was investigated. MATERIALS AND METHODS:
Obstetric histories of 154 anti-Ro/SSA-positive women with autoimmune
diseases [78 systemic lupus erythematosus (SLE) and 76 non- SLE] were
analysed and compared to a control group of 142 anti-Ro/SSA- negative women
(71 SLE and 71 non-SLE) matched for disease diagnosis and age at the time
of anti-Ro/SSA diagnosis. Obstetric history was also obtained and analysed
from a group of healthy women, frequency matched to anti-Ro/SSA-positive
women on age at study entry. RESULTS: The rate of pregnancy loss and
adverse pregnancy outcome did not differ significantly between
anti-Ro/SSA-positive women, anti-Ro/SSA-negative women and healthy
controls. Anti-Ro/SSA-positive SLE women reported a significantly higher
rate (18.0%) of therapeutic abortions compared to anti-Ro/SSA-negative
women (5.6%, P=0.0244) and healthy controls (4.6%, P=0.0013). Anti-Ro/SSA
non-SLE-positive women reported a significantly higher rate (23.7%) of
recurrent pregnancy loss in comparison to anti- Ro/SSA-negative women
(7.04%, P=0.0063) and healthy controls (6.4%, P=0.0004). CONCLUSIONS:
Although anti-Ro/SSA antibody does not adversely affect pregnancy outcome
in SLE patients, it appears to be associated with recurrent pregnancy loss
in non-SLE patients.
ORIGINAL PAPERS
Pregnancy outcome and anti-Ro/SSA in autoimmune diseases: a retrospective cohort study
Department of Pathophysiology, School of Medicine, National University of Athens, Greece.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Gerosa, R. Cimaz, M. Stramba-Badiale, K. Goulene, E. Meregalli, L. Trespidi, B. Acaia, R. Cattaneo, A. Tincani, M. Motta, et al. Electrocardiographic abnormalities in infants born from mothers with autoimmune diseases a multicentre prospective study Rheumatology, August 1, 2007; 46(8): 1285 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N Schwartz, Y Shoenfeld, O Barzilai, R Cervera, J Font, M Blank, S Yacobi, N Patlas, A Cohen, D Mevorach, et al. Reduced placental growth and hCG secretion in vitro induced by antiphospholipid antibodies but not by anti-Ro or anti-La: studies on sera from women with SLE/PAPS Lupus, February 1, 2007; 16(2): 110 - 120. [Abstract] [PDF]
|
|
|
|
|
|
A Tincani, D Bompane, E Danieli, and A Doria Pregnancy, lupus and antiphospholipid syndrome (Hughes syndrome) Lupus, March 1, 2006; 15(3): 156 - 160. [Abstract] [PDF]
|
|
|
|
 |
|
 A. J. Wolfberg, A. Lee-Parritz, A. J. Peller, and E. S. Lieberman Association of Rheumatologic Disease With Preeclampsia Obstet. Gynecol., June 1, 2004; 103(6): 1190 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Brucato, A Doria, M Frassi, G Castellino, F Franceschini, D Faden, M P. Pisoni, L Solerte, M Muscara, A Lojacono, et al. Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study Lupus, November 1, 2002; 11(11): 716 - 721. [Abstract] [PDF]
|
|
|
|
|
|
P. E. Georgiou, E. N. Politi, P. Katsimbri, V. Sakka, and A. A. Drosos Outcome of lupus pregnancy: a controlled study Rheumatology, September 1, 2000; 39(9): 1014 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Mavragani, J. P. A. Ioannidis, A. G. Tzioufas, I. E. Hantoumi, and H. M. Moutsopoulos Recurrent pregnancy loss and autoantibody profile in autoimmune diseases Rheumatology, December 1, 1999; 38(12): 1228 - 1233. [Abstract] [Full Text] [PDF]
|
|