The British Journal of Rheumatology, Vol 37, 854-861, Copyright © 1998 by British Society for Rheumatology
H Sugimoto, A Takeda and S Kano
We attempted to assess whether pannus volume measured by magnetic resonance
imaging (MRI) can be used as an indicator of disease activity in rheumatoid
arthritis (RA). Eleven women (mean age 46 yr) with uncontrolled RA were
studied for 1 yr. Pannus formation in both hands was quantified using MRI
at the start of the study, and at 6 and 12 months thereafter. The volume of
enhancing pannus (VEP) was compared with changes in the radiological
scores, grip strength, joint tenderness counts, joint swelling counts,
erythrocyte sedimentation rate (ESR), and serum C-reactive protein (CRP).
Patients were classified into three groups based on VEP changes between 0
and 12 months: unchanged (n = 2), decreased (n = 6) and increased (n = 3).
VEP at 6 months and at 12 months differed significantly between the three
groups. No statistically significant differences were found between the
groups in radiographic scores, physical parameters or laboratory parameters
despite the fact that some of these parameters changed in the direction
indicated by the changes in VEP. VEP can be used as a new indicator to
assess disease activity in individual RA patients and, using this
parameter, treatment outcome can be assessed in fewer subjects than with
traditional measures.
ORIGINAL PAPERS
Assessment of disease activity in rheumatoid arthritis using magnetic resonance imaging: quantification of pannus volume in the hands
Department of Radiology, Jichi Medical School, Japan.
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