The British Journal of Rheumatology, Vol 37, 883-888, Copyright © 1998 by British Society for Rheumatology
FI Romero, O Amengual, T Atsumi, MA Khamashta, FJ Tinahones and GR Hughes
The prevalence and clinical significance of antibodies against beta2-
glycoprotein I (anti-beta2GPI) and antibodies against oxidized low- density
lipoprotein (anti-ox-LDL) were evaluated as potential indicators of
arterial disease in patients with systemic lupus erythematosus (SLE) and
SLE with secondary antiphospholipid syndrome (APS). IgG anti-beta2GPI and
IgG anti-ox-LDL were measured by enzyme- linked immunosorbent assay (ELISA)
in serum samples from 118 patients with SLE, including 40 with secondary
APS. IgG anti-beta2GPI were positive in 17% (20/118) of SLE patients. The
presence and titres of IgG anti-beta2GPI were strongly associated with a
history of arterial thrombosis. Haemolytic anaemia was also significantly
associated with the presence of IgG anti-beta2GPI. The prevalence of IgG
anti-ox-LDL was 53% (63/118), but there was no association with arterial
thrombosis. No correlation between the values of anti-ox-LDL and those of
anti-beta2GPI was found. These results suggest that IgG anti- beta2GPI
could be a marker for arterial thrombosis in SLE patients, while IgG
anti-ox-LDL were not associated with arterial disease in this group of
lupus patients.
ORIGINAL PAPERS
Arterial disease in lupus and secondary antiphospholipid syndrome: association with anti-beta2-glycoprotein I antibodies but not with antibodies against oxidized low-density lipoprotein
Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London.
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