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The British Journal of Rheumatology, Vol 37, 908-911, Copyright © 1998 by British Society for Rheumatology

ORIGINAL PAPERS

Methotrexate treatment in Felty's syndrome

S Wassenberg, G Herborn and R Rau
Department of Rheumatology, Evangelisches Fachkrankenhaus, Ratingen, Germany.

Felty's syndrome is a rare disorder characterized as a systemic manifestation of severe rheumatoid arthritis associated with granulocytopenia and splenomegaly. We report a retrospective analysis of a series of seven patients treated successfully with low-dose methotrexate. leading to sustained clinical improvement (number of swollen joints) and normalization of the granulocyte count for an observation period of 1 yr. Our cohort is the largest ever published with methotrexate treatment of this rare condition. Our results confirm earlier single case reports suggesting methotrexate to be the first- choice treatment nowadays in Felty's syndrome.
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