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The British Journal of Rheumatology, Vol 37, 988-991, Copyright © 1998 by British Society for Rheumatology

ORIGINAL PAPERS

Interleukin-10 promoter polymorphisms in rheumatoid arthritis and Felty's syndrome

G Coakley, CC Mok, AH Hajeer, WE Ollier, D Turner, PJ Sinnott, IV Hutchinson, GS Panayi and JS Lanchbury
Department of Rheumatology, Guy's, King's and St Thomas' School of Medicine, Guy's Hospital, London.

OBJECTIVE: To examine whether promoter polymorphisms associated with variation in interleukin-10 (IL-10) production are relevant to the development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS: DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The promoter region between -533 and - 1120 was amplified by polymerase chain reaction, and polymorphisms detected by restriction enzyme digest or sequence-specific oligonucleotide probing. RESULTS: We found no significant difference in allele or haplotype frequencies between the groups. CONCLUSION: There is no association between FS or RA and these recently identified IL-10 promoter polymorphisms. Other genetic or environmental factors could explain the alterations in IL-10 levels seen in these conditions.
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