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Rheumatology 1999; 38: 1142-1144
© 1999 British Society for Rheumatology

Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus

H. Nakashima, M. Akahoshi, Y. Tanaka, K. Yamaoka, E. Ogami, S. Nagano, Y. Arinobu, H. Niiro, T. Otsuka and Y. Niho

First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Correspondence to: H. Nakashima, First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, 812-8582, Japan.

Objective. To assess the association between polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) and systemic erythematosus (SLE) in Japanese people.

Method. We examined the IL-10 receptor genotype of 109 SLE patients and 102 healthy subjects by the reverse transcription-polymerase chain reaction-restriction fragment length polymorphism (RT-PCR-RFLP) method.

Results. There was no difference in the IL10R genotype frequencies of these two groups.

Conclusion. The IL10R genotype does not determine susceptibility to SLE in Japanese people.

KEY WORDS: IL-10, IL-10 receptor gene (IL10R), Polymorphism, Susceptibility, Systemic lupus erythematosus


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