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Rheumatology 1999; 38: 1203-1207
© 1999 British Society for Rheumatology

The relative proportions of secreted interleukin-2 and interleukin-10 determine the magnitude of rheumatoid arthritis T-cell proliferation to the recall antigen tuberculin purified protein derivative

V. M. Corrigall, A. Garyfallos1 and G. S. Panayi

Department of Rheumatology, Guy's, King's and St Thomas' School of Medicine, King's College, Guy's Campus, London SE1 9RT, UK and
1 Aristotle University of Thessaloniki, Fourth Department of Medicine, Hippocration General Hospital, Thessoloniki 540 06, Greece

Correspondence to: V. M. Corrigall, Department of Rheumatology, 5th Floor Thomas Guy House, Guy's Hospital, St Thomas Street, London SE1 9RT, UK.

Objective. To investigate the mechanisms of the deficient proliferative responses by rheumatoid arthritis (RA) peripheral blood T cells to the recall antigen tuberculin purified protein derivative (PPD).

Methods. The concomitant production of interleukin (IL)-2, IL-10 and lymphocyte proliferation were studied by enzyme-linked immunosorbent assay and [3H]thymidine uptake, respectively, in 12 normal controls and eight RA patients.

Results. An inverse correlation was found between IL-10 production and proliferation to PPD. The proliferative response was shown to be critically affected by the IL-2:IL-10 ratio so that absolute levels of secreted IL-2 or IL-10 correlated non-significantly with lymphocyte proliferation.

Conclusion. The deficient T-cell proliferation in RA peripheral blood mononuclear cells is related to the relative proportions of IL-2:IL-10 rather than the absolute amounts secreted.

KEY WORDS: T lymphocyte, IL-2, IL-10, Recall antigens


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