A preliminary study of ultrasound aspiration of bone erosion in early rheumatoid arthritis

doi:10.1093/rheumatology/38.4.329

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A preliminary study of ultrasound aspiration of bone erosion in early rheumatoid arthritis

D Mc Gonagle, W Gibbon, P O'Connor, D Blythe, R Wakefield, M Green, D Veale and P Emery
The Rheumatology Research Unit, University of Leeds, UK.

OBJECTIVE: To develop a new technique to assess the primary lesion in early rheumatoid arthritis (RA). METHODS: Ten patients with early RA and radiographically or MRI confirmed erosions had a needle introduced into the base of the erosion under sonographic guidance. Material was then aspirated from this site. RESULTS: The procedure was well tolerated with no complications. Small samples of necrotic bone and tissue were obtained in five out of 10 cases. In one case, a distinctive population of pleomorphic CD34 + cells with characteristics of bone marrow progenitors was isolated. Tissue invading bone with a characteristic appearance of pannus was not seen. CONCLUSION: A new method of sampling the earliest lesion in RA is described. The findings raise questions about the nature of bone damage in early RA.
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				K. Raza, C. Y. Lee, D. Pilling, S. Heaton, R. D. Situnayake, D. M. Carruthers, C. D. Buckley, C. Gordon, and M. Salmon Ultrasound guidance allows accurate needle placement and aspiration from small joints in patients with early inflammatory arthritis Rheumatology, August 1, 2003; 42(8): 976 - 979. [Abstract] [Full Text] [PDF]

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