Rheumatology, Vol 38, 448-452, Copyright © 1999 by British Society for Rheumatology
A Perdriger, P Guggenbuhl, G Chales, J Yaouanq, E Quelvennec, MN Bonnard, Y Pawlotsky and G Semana
OBJECTIVE: HLA DM is a non-classical major histocompatibility complex (MHC)
class II molecule that has been shown to facilitate peptide loading with
classical class II molecules. METHODS: In this study, we analysed the
polymorphism in exon 3 of HLA DMA and DMB genes by a polymerase chain
reaction-sequence-specific oligonucleotide probe method in 163 rheumatoid
arthritis (RA) patients and 146 ethnically matched controls. The HLA-DRB1
genotype was also analysed by a reverse- dot blot method. RESULTS: Our
results show in RA patients a significant increase in the HLA DMB*0101
allele frequency (83% vs 72.3% of the controls, P < 1.6 x 10(-3),
significance at P < 0.0125) and in the HLA DMB*0101-0101 homozygote
genotype frequency [70.8% vs 50% of the controls, P < 4.2 x 10(-4),
significance at P < 0.00625, odds ratio (OR) = 2.4, 95% confidence
interval (CI): 1.43-4]. The increase in DMB*0101 allele and homozygote
genotype frequencies was independent of a linkage disequilibrium between
DMB and DRB1 alleles. The analysis of non-random associations between the
HLA-DM and DRB1 alleles only revealed a significant association in controls
between DMB*0104 and DRB1*07 alleles (delta = 0.01, P < 7 x 10(-4),
significance at P < 9.6 x 10(-4)). On the other hand, the DMB*0101-0102
genotype frequency was increased in DRB1*0401-negative RA patients as
compared to controls (11% vs 2%, P < 0.011, significance at P <
0.015, OR = 6.2, 95% CI: 1.2- 30). CONCLUSION: Our data suggest that HLA-DM
alleles could play a role in the genetic susceptibility to RA.
ORIGINAL PAPERS
Positive association of the HLA DMB1*0101-0101 genotype with rheumatoid arthritis
Department of Rheumatology, Teaching Hospital, Rennes, France.
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