Rheumatology, Vol 38, 457-462, Copyright © 1999 by British Society for Rheumatology
I Krause, Y Uziel, D Guedj, M Mukamel, L Harel, Y Molad and A Weinberger
OBJECTIVE: To study the clinical spectrum of Behcet's disease (BD) in
childhood, in comparison to adult-onset disease. METHODS: Nineteen
children, who fulfilled disease criteria up to the age of 16 yr, were
studied. The results were compared to those of 34 adult patients with BD.
An activity index and severity score were calculated for both study groups.
RESULTS: The mean age of disease onset was 6.9+/-3.9 yr, similar ages of
onset were found in males and females. The clinical spectrum of childhood
BD resembled that of adult disease; however, the prevalence of certain
manifestations was different between children and adults. Children with BD
had significantly less genital ulcers, less vascular thromboses and more
non-specific gastrointestinal symptoms, as well as central nervous system
involvement and arthralgia. A relatively high prevalence of uveitis was
found in childhood BD. The activity index and severity score were
significantly lower in children than in adults. CONCLUSION: Our results
point to a similar systemic expression of BD in children and adults;
however, the disease seems to run a less severe course in children.
ORIGINAL PAPERS
Childhood Behcet's disease: clinical features and comparison with adult- onset disease
Rheumatology Unit, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva, Israel.
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