Skip Navigation

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (56)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Wong, C. K.
Right arrow Articles by Lam, C. W. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wong, C. K.
Right arrow Articles by Lam, C. W. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2000; 39: 1078-1081
© 2000 British Society for Rheumatology

Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus

C. K. Wong, E. K. Li1, C. Y. Ho and C. W. K. Lam

Departments of Chemical Pathology and
1 Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong, China

Background. Previous studies have indicated that the autoimmune phenomenon might be caused by an imbalance of T-helper cell (Th) cytokines.

Methods. We investigated the plasma concentrations of a novel pro-inflammatory Th1 cytokine, interleukin (IL)-18, and its inducer, IL-12, in patients with systemic lupus erythematosus (SLE) and correlated them with the SLE disease activity index (SLEDAI). Plasma IL-18 and IL-12 concentrations of 40 SLE patients and 18 sex- and age-matched control subjects were measured by enzyme-linked immunosorbent assay.

Results. Plasma IL-18 and IL-12 concentrations were significantly higher in SLE patients than in control subjects [median (interquartile range): IL-18, 320.0 pg/ml (164.4–475.6 pg/ml) vs 130.1 pg/ml (57.8–202.4 pg/ml), P < 0.001; IL-12, 143.3 pg/ml (39.4–247.2 pg/ml) vs 84.7 pg/ml (29.3–140.1 pg/ml), P < 0.001]. Increases in IL-18 concentration correlated positively and significantly with SLEDAI score (r = 0.449, P = 0.004).

Conclusion. The novel cytokine IL-18 might play a crucial role in triggering the inflammatory processes in SLE.

KEY WORDS: Interleukin-18, Interleukin-12, Systemic lupus erythematosus, T-helper cell cytokines.

Correspondence to: C. W. K. Lam.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
T. K. Tso, W.-N. Huang, H.-Y. Huang, and C.-K. Chang
Relationship of plasma interleukin-18 concentrations to traditional and non-traditional cardiovascular risk factors in patients with systemic lupus erythematosus
Rheumatology, September 1, 2006; 45(9): 1148 - 1153.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
A Wozniacka, A Lesiak, J Narbutt, D P McCauliffe, and A Sysa-Jedrzejowska
Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients
Lupus, May 1, 2006; 15(5): 268 - 275.
[Abstract] [PDF]

Home page
 LupusHome page
T K Tso, W-N Huang, H-Y Huang, and C-K Chang
Elevation of plasma interleukin-18 concentration is associated with insulin levels in patients with systemic lupus erythematosus
Lupus, April 1, 2006; 15(4): 207 - 212.
[Abstract] [PDF]

Home page
 Rheumatology (Oxford)Home page
C. K. Wong, L. C. W. Lit, L. S. Tam, E. K. Li, and C. W. K. Lam
Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus
Rheumatology, August 1, 2005; 44(8): 989 - 994.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
C. K. Wong, L. C. W. Lit, L. S. Tam, E. K. Li, and C. W. K. Lam
Elevation of plasma osteopontin concentration is correlated with disease activity in patients with systemic lupus erythematosus
Rheumatology, May 1, 2005; 44(5): 602 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Bossu, D. Neumann, E. Del Giudice, A. Ciaramella, I. Gloaguen, G. Fantuzzi, C. A. Dinarello, E. Di Carlo, P. Musiani, P. L. Meroni, et al.
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
PNAS, November 25, 2003; 100(24): 14181 - 14186.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. A. Gracie, S. E. Robertson, and I. B. McInnes
Interleukin-18
J. Leukoc. Biol., February 1, 2003; 73(2): 213 - 224.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
E Robak, A Wozaniacka, A Sysa-Jedrzejowska, H Stepien, and T Robak
Circulating angiogenesis inhibitor endostatin and positive endothelial growth regulators in patients with systemic lupus erythematosus
Lupus, June 1, 2002; 11(6): 348 - 355.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
E. Esfandiari, I. B. McInnes, G. Lindop, F.-P. Huang, M. Field, M. Komai-Koma, X.-q. Wei, and F. Y. Liew
A Proinflammatory Role of IL-18 in the Development of Spontaneous Autoimmune Disease
J. Immunol., November 1, 2001; 167(9): 5338 - 5347.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Kubota, J. Fang, R. A. Brown, and J. M. Krueger
Interleukin-18 promotes sleep in rabbits and rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R828 - R838.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
D Sen and R W Keen
Osteoporosis in systemic lupus erythematosus: prevention and treatment
Lupus, March 1, 2001; 10(3): 227 - 232.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.