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Rheumatology 2000; 39: 1121-1125
© 2000 British Society for Rheumatology

31P magnetic resonance spectroscopy in fibromyalgic muscle

H. Sprott1,2,, R. Rzanny3, J. R. Reichenbach3, W. A. Kaiser3, G. Hein2 and G. Stein2

1 Department of Rheumatology and Institute of Physical Medicine, University Hospital Zürich, Switzerland,
2 Department of Internal Medicine IV and
3 Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Germany

Objective. To measure inorganic phosphate (Pi), phosphocreatine (PCr), ATP and phosphodiesters (PDE) in fibromyalgic muscle tissue by 31P magnetic resonance spectroscopy.

Methods. A 1.5 Tesla scanner with a P 100 surface coil was used to examine 15 patients (mean age 49.9 ± 14.3 yr) with fibromyalgia, according to the American College of Rheumatology criteria, and 17 healthy controls (mean age 30.2 ± 5.8 yr).

Results. Compared with the controls, there were increases in the levels of PDE (+22%, P = 0.032) and Pi (+19%, P = 0.019) in the spectra of fibromyalgia patients, but there was no difference in pH.

Conclusion. The metabolic differences we found may have been related to weakness and fatigue in the fibromyalgia patients, but they do not fully explain the fibromyalgia symptoms.

KEY WORDS: Fibromyalgia, Magnetic resonance spectroscopy, Phosphate, ATP, Phosphocreatine, Phosphodiesters.

Correspondence to: H. Sprott, Department of Rheumatology and Institute of Physical Medicine, University Hospital Zürich, Gloriastrasse 25, CH-8091 Zürich, Switzerland.


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