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Rheumatology 2000; 39: 148-155
© 2000 British Society for Rheumatology

Development of a disease activity index for the assessment of reactive arthritis (DAREA)

G. Eberl1,2, A. Studnicka-Benke2, H. Hitzelhammer2, F. Gschnait3 and J. S. Smolen1,2,4

1 Division of Rheumatology, Department of Internal Medicine III, University of Vienna and
2 Second Department of Internal Medicine (Centre of Diagnosis and Treatment of Rheumatic Diseases) and
3 Department of Dermatology, Lainz Hospital, Austria

Objectives. The objectives of this study were to investigate and validate individual variables and to develop a composite score for disease activity measurement in patients with reactive arthritis (REA).

Methods. In the first cross-sectional part, the clinical and laboratory evaluation of 45 patients was used to elaborate the most important individual disease activity measures. In the second prospective part, these variables as well as a composite score for disease activity measurement of REA were prospectively validated in 23 patients at two points in time.

Results. The following variables emerged as the most useful for the composite measure: number of swollen and tender joints, patient's pain and global assessment, and C-reactive protein. The score was calculated by simple addition of the individual figures.

Conclusion. DAREA constitutes a reliable score which can easily be assessed on a day-to-day office work basis.

KEY WORDS: Disease activity, Reactive arthritis, Outcome measurement

4 Correspondence to: J. S. Smolen, Division of Rheumatology, Department of Internal Medicine III, University of Vienna, Waehringer Guertel 18–20, A-1090 Vienna, Austria.


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