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Rheumatology 2000; 39: 674-679
© 2000 British Society for Rheumatology

Grand Rounds in Rheumatology

The possible role of myocardial biopsy in systemic sclerosis

O. Liangos, L. Neure, U. Kühl1, M. Pauschinger1, J. Sieper, A. Distler, P. L. Schwimmbeck1 and J. Braun

Department of Nephrology and Rheumatology and
1 Department of Cardiology and Pulmonology, Freie Universität Berlin, Universitätsklinikum Benjamin Franklin, 12200 Berlin, Germany

Abstract

The histopathological features of heart involvement in systemic sclerosis (SSc) are not widely known. In internal and transplantation medicine, myocardial biopsies are increasingly used to diagnose cardiomyopathies including myocarditis. In two SSc patients presenting with dyspnoea with no evidence of pulmonary involvement, the cause of the compromised heart function was sought by myocardial biopsy. Immunohistological analysis revealed an increased number of CD3+ + T cells indicating myocarditis in one, and increased amounts of fibroblasts in both SSc patients. The authors think that myocardial involvement in SSc should be differentially evaluated and they propose the use of myocardial biopsies as a tool to distinguish between inflammatory and fibrotic forms of heart involvement in SSc patients.

Notes

Correspondence to: J. Braun.


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