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Rheumatology 2000; 39: 1037-1039
© 2000 British Society for Rheumatology

Dermatomyositis associated with the presence of parvovirus B19 DNA in muscle

G. Chevrel, A. Calvet1, V. Belin and P. Miossec

Department of Immunology and Rheumatology, Hôpital E. Herriot and
1 Department of Virology, Domaine Rockefeller, Lyon, France

We report a case of dermatomyositis associated with molecular evidence of parvovirus B19 DNA in two muscle biopsies collected 5 months apart. IgG- but not IgM-specific antibodies were detected in serum. None of four serum samples was positive for parvovirus B19 DNA. The two biopsies contained B19 VP1 sequences and the second one was also positive for NS1. This is the first report of viral parvovirus B19 DNA in muscle of a patient with dermatomyositis. Latent muscle infection may contribute to the clinical picture.

KEY WORDS: Dermatomyositis, Autoimmune disease, Parvovirus B19, Muscle biopsy, Polymerase chain reaction

Correspondence to: G. Chevrel, Department of Immunology and Rheumatology, Hôpital E. Herriot, 5 place d'Arsonval, 69437 Lyon Cedex 03, France.


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