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Rheumatology 2000; 39: 21-28
© 2000 British Society for Rheumatology

SUPPLEMENT

Celecoxib clinical profile

L. Tive

Clinical Research, Pfizer Inc, New York, NY, USA

Correspondence to: Correspondence to: L. Tive, Director, Clinical Research, Pfizer Inc, New York, NY, USA.

Abstract

Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis. For both OA and RA, celecoxib has been shown to be significantly superior in efficacy to placebo and similar in efficacy to traditional non-steroidal anti-inflammatory drugs. Its advantage, however, is its gastrointestinal (GI) safety. Randomized clinical trials as well as long-term outcomes studies have demonstrated that the GI safety profile of celecoxib is superior to that of traditional NSAIDs and similar to that of placebo. Additionally, the renal and cardiovascular safety of celecoxib has also become apparent, as well as its efficacy, tolerability and safety in the elderly population.

KEY WORDS: Celecoxib, COX-2 inhibitors, NSAIDs, Osteoarthritis, Rheumatoid arthritis, Gastrointestinal safety


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