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Rheumatology 2000; 39: 51-56
© 2000 British Society for Rheumatology

SUPPLEMENT

The Swedish ACCES model

predicting the health economic impact of celecoxib in patients with osteoarthritis or rheumatoid arthritis

U. Haglund and P. Svarvar1

Department of Surgery, Uppsala University, University Hospital, Uppsala
1 Outcomes Research, Medical Department, Pfizer AB, Sweden

Correspondence to: Correspondence to: U. Haglund, Department of Surgery, Uppsala University, University Hospital, Uppsala, Sweden.

Abstract

The Arthritis Cost Consequence Evaluation System (ACCES) pharmacoeconomic model was used to evaluate the economic and health impact of the recent introduction of celecoxib for treatment of osteoarthritis (OA) and rheumatoid arthritis (RA) in Sweden. The model demonstrates that use of celecoxib can be expected to reduce the incidence of gastrointestinal adverse events, resource utilization and treatment costs. In a cost-effectiveness analysis, celecoxib demonstrated economic dominance (i.e. improved health at reduced cost) compared with the currently available alternatives for OA, and demonstrated economic dominance against a clinically relevant base-case scenario for RA. In sensitivity analyses, the results were shown to be relatively robust; celecoxib demonstrated economic dominance or favourable cost-effectiveness ratios in all analyses. Based on these data, it can be concluded that the use of celecoxib in Sweden will provide societal benefits by improving health care at reduced cost for patients with OA and RA.

KEY WORDS: Pharmacoeconomics, Health outcomes, NSAIDs, Celecoxib, Sweden, Cost-effectiveness


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