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Rheumatology 2001; 40: 31-36
© 2001 British Society for Rheumatology

HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients

R. Caliz, T. Atsumi, E. Kondeatis1, O. Amengual, M. A. Khamashta, R. W. Vaughan1, J. S. Lanchbury2 and G. R. V. Hughes

Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London,
1 Tissue Typing Department, Guy's Hospital, London,
2 Molecular Immunogenetics Division of Medicine, UMDS, London, UK

Objectives. We investigated the association between HLA class II haplotypes and antiphospholipid syndrome (APS).

Methods. HLA DRB1, DQB1 and DQA1 genotypes were determined by the polymerase chain reaction using sequence-specific primers in 83 Caucasoid British patients with APS. The genotype frequencies were compared between subgroups of patients and 177 healthy controls.

Results. DQB1*0604/5/6/7/9-DQA1*0102-DRB1*1302 and DQB1*0303-DQA1*0201-DRB1*0701 haplotypes showed significantly positive correlations with APS [P=0.0087 and P=0.0012, respectively]. The association of the former was enhanced in primary APS patients with anti-ß2-glycoprotein I antibodies (anti-ß2GPI) [odds ratio 6.2, 95% confidence interval (2.2–17.6), P=0.0014, corrected P=0.042].

Conclusions. These alleles and haplotypes might affect anti-ß2GPI production and APS development in different and heterogeneous fashion.

Correspondence to: M. A. Khamashta, Lupus Research Unit, the Rayne Institute, St Thomas' Hospital, London SE1 7EH, UK


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