Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (1)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Shadidi, K. R.
Right arrow Articles by Thompson, K. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Shadidi, K. R.
Right arrow Articles by Thompson, K. M.
Related Collections
Right arrow Rheumatoid Arthritis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2001; 40: 1120-1125
© 2001 British Society for Rheumatology

Original Papers

T-cell responses to viral, bacterial and protozoan antigens in rheumatoid inflammation. Selective migration of T cells to synovial tissue

K. R. Shadidi, T. Aarvak, S. Jeansson1, J. E. Henriksen2, J. B. Natvig and K. M. Thompson

The National Hospital, Institute of Immunology, Department of Rheumatology Research, Oslo,
1 Ullevål University Hospital, Department of Microbiology, Oslo and
2 Diakonhjemmets Hospital, Department of Rheumatology, Oslo, Norway

Objective. To identify any preferential or selective migration of T-cell specificities to inflamed tissues of rheumatoid arthritis (RA) patients.

Methods. Lymphocytes from peripheral blood (PB) and synovial tissue (ST) were isolated from RA patients and stimulated with a panel of crude antigen preparations from 18 bacterial, protozoan and viral sources. Proliferative responses of the T lymphocytes to each antigen and group of antigens were compared in PB and ST. Antigen-specific T-cell clones were developed and their migratory capacities towards synovial chemokines were compared.

Results. ST-derived T cells showed a small but significantly higher stimulation index (SI) to the group of intestinal bacteria compared with PB T cells. Conversely, responses of ST-derived T cells to Acanthamoeba polyphaga (AP) were both profoundly and significantly lower compared with PB-derived T cells. The viral antigens as a whole gave comparable reactivities in blood and ST. The migratory capacity of AP-specific T-cell clones towards chemokines produced by ST was profoundly poorer compared with Campylobacter jejuni- and herpes simplex virus-specific T-cell clones.

Conclusions. The results indicate a selective migration of T cells of given specificities to the inflamed rheumatoid synovium.

KEY WORDS: Rheumatoid arthritis, Antigens, Proliferation, Intestinal bacteria, Acanthamoeba polyphaga, Migration.

Correspondence to: K. R. Shadidi, The National Hospital, Institute of Immunology, Department of Rheumatology Research, N-0027 Oslo, Norway.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.