| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Rheumatology 2001; 40: 1346-1354
© 2001 British Society for Rheumatology
Original Papers |
Increased endothelial expression of HLA-DQ and interleukin 1
in extra-articular rheumatoid arthritis. Results from immunohistochemical studies of skeletal muscle
Department of Rheumatology, Malmö University Hospital,
1 Unit of Rheumatology, Department of Medicine, Karolinska Hospital, Stockholm,
2 Department of Rheumatology, Lund University Hospital,
3 Department of Laboratory Medicine, Section of MIG, Lund University Hospital and
4 Department of Microbiology, Pathology and Immunology, Division of Pathology, Huddinge Hospital, Stockholm, Sweden
Objective. To investigate markers of endothelial activation in muscle biopsies from rheumatoid arthritis (RA) patients with and without extra-articular manifestations (ExRA).
Patients and methods. Nine consecutive ExRA patients were compared with nine RA controls without ExRA, matched for age, sex and duration of RA. Muscle biopsies were obtained from the lateral vastus or anterior tibial muscle. Macrophage and lymphocyte CD markers, HLA molecules, cytokines and adhesion molecules were investigated using immunohistochemistry, and stainings were evaluated using computer image analysis and conventional microscopy. Serum concentrations of soluble adhesion molecules, tumour necrosis factor 
(TNF-) and rheumatoid factor (RF) were determined using immunoassays.
Results. The number of HLA-DQ-positive capillaries (P=0.039) and the expression of interleukin 1 (IL-1) in endothelial cells (mean pairwise difference 0.26%; 95% confidence interval 0–0.52) were increased in ExRA patients compared with non-ExRA controls. There were no signs of inflammatory cell infiltrates or fibre degeneration. Serum levels of TNF-, the soluble form of intercellular adhesion molecule 1, the soluble form of vascular cell adhesion molecule 1 and IgM RF were increased in the ExRA group.
Conclusion. The increased expression of HLA-DQ and IL-1 may indicate systemic endothelial activation in extra-articular RA, which could be of importance for cardiovascular comorbidity and mortality in such patients.
KEY WORDS: Rheumatoid arthritis, Extra-articular manifestations, Endothelial activation, Interleukin-1, HLA-DQ, Cardiovascular disease, Vasculitis.
Correspondence to: C. Turesson, Department of Rheumatology, Malmö University Hospital, S-205 02 Malmö, Sweden
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C Turesson, L T H Jacobsson, G Sturfelt, E L Matteson, L Mathsson, and J Ronnelid Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis Ann Rheum Dis, January 1, 2007; 66(1): 59 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lindehammar and B. Lindvall Muscle involvement in juvenile idiopathic arthritis Rheumatology, December 1, 2004; 43(12): 1546 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Turesson, W M O'Fallon, C S Crowson, S E Gabriel, and E L Matteson Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years Ann Rheum Dis, August 1, 2003; 62(8): 722 - 727. [Abstract] [Full Text] [PDF]
|
|