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Rheumatology 2001; 40: 406-409
© 2001 British Society for Rheumatology

Renal vascular damage in Japanese patients with systemic sclerosis

C. Nishijima, S. Sato, M. Hasegawa, T. Nagaoka, A. Hirata1, K. Komatsu1 and K. Takehara

Department of Dermatology and
1 Department of Urology, Kanazawa University School of Medicine, Kanazawa 920-8641, Japan

Objective. To evaluate renal vascular damage in Japanese patients with systemic sclerosis (SSc) by colour-flow Doppler ultrasonography.

Methods. The pulsatility index (PI) was measured in renal interlobar and segmental arteries by colour-flow Doppler ultrasonography.

Results. PI values of interlobar arteries were increased in SSc patients (n=53) with normal renal function compared with healthy persons (n=16), systemic lupus erythematosus patients (n=12) and dermatomyositis patients (n=3). SSc patients with elevated PI levels had digital pitting scar, short sublingual frenulum, contracture of phalanges, pulmonary fibrosis, decreased per cent vital capacity, heart involvement, positivity for anti-topoisomerase I antibody, and elevated C-reactive protein more frequently than those with normal PI levels.

Conclusion. Although renal crisis is rare in Japanese SSc patients, our study suggests that latent and subclinical renal damage exists in these patients.

KEY WORDS: Systemic sclerosis, Colour-flow Doppler ultrasonography, Pulsatility index, Vascular damage, Kidney.

Correspondence to: S. Sato, Department of Dermatology, Kanazawa University School of Medicine, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan


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