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Rheumatology 2001; 40: 574-578
© 2001 British Society for Rheumatology

Paediatric Rheumatology

Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis

Paediatric Rheumatology/Series Editor: P. Woo

E. Crawley, S. Kon and P. Woo

Department of Molecular Pathology, University College London Medical School, London, UK

Abstract

Objective. To determine whether children with extended oligoarticular juvenile idiopathic arthritis (JIA) produce less of the anti-inflammatory cytokine interleukin-10 (IL-10) than those with persistent oligoarticular JIA.

Methods. We measured IL-10 production in the parents of children with oligoarticular or extended oligoarticular JIA, from whole-blood cultures stimulated with lipopolysaccharide.

Results. IL-10 production was lower in the parents of children with extended oligoarticular JIA compared with those of children with oligoarticular JIA (P=0.034). There was an increase in the percentage of ATA-containing genotypes (i.e. genotypes ATA/ATA, ATA/ACC or ATA/GCC) in the parents of children with extended oligoarticular JIA compared with healthy controls (P<0.02) but not in the parents of children with oligoarticular JIA.

Conclusions. As approximately 84% of the variation in IL-10 production is thought to be genetically regulated, these results suggest that stimulated IL-10 production would be lower in children with extended oligoarticular JIA. Because IL-10 is an anti-inflammatory cytokine, this may partly explain why this group of children has more severe disease.

KEY WORDS: JIA, Interleukin-10, Single nucleotide polymorphism, Genes, Hereditary, Oligoarticular.

Notes

Correspondence to: E. Crawley, Molecular Pathology, UCLMS, 3rd Floor, Windeyer Institute, 46 Cleveland Street, London W1T 4JF, UK.


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