Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (29)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Aringer, M.
Right arrow Articles by Graninger, W. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aringer, M.
Right arrow Articles by Graninger, W. B.
Related Collections
Right arrow Systemic Lupus Erythematosus and Autoimmunity
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2001; 40: 876-881
© 2001 British Society for Rheumatology

Original Papers

Serum interleukin-15 is elevated in systemic lupus erythematosus

M. Aringer1, G. H. Stummvoll1, G. Steiner1, M. Köller1, C. W. Steiner1, E. Höfler2, H. Hiesberger1, J. S. Smolen1,2, and W. B. Graninger1

1 Department of Rheumatology, Internal Medicine III, University of Vienna and
2 Department of Internal Medicine II, Lainz Hospital, Vienna, Austria

Objective. To investigate if interleukin-15 (IL-15) (rather than IL-2) is increased in systemic lupus erythematosus (SLE) and might be responsible for immunological abnormalities of SLE such as the increased lymphocytic expression of Bcl-2 and CD25.

Methods. Serum IL-15, IL-2 and tumour necrosis factor (TNF) levels of 65 SLE patients, 20 healthy persons and 10 rheumatoid arthritis (RA) patients were measured by enzyme-linked immunosorbent assay (ELISA). For 25 SLE patients, the percentage of CD25 + lymphocytes and the lymphocytic Bcl-2 levels were simultaneously determined by fluorocytometry. Peripheral blood mononuclear cells (PBMC) of 15 SLE patients were incubated with or without recombinant IL-15 and the influence on Bcl-2 and CD25 was determined.

Results. IL-15 was found to be elevated in 25 SLE sera (38%), but in none of the 20 healthy sera (P = 0.0005) and none of the 10 RA sera. Both lymphocyte CD25 and Bcl-2 expression significantly correlated with serum IL-15 and were increased by recombinant IL-15.

Conclusion. Serum IL-15 may in part be responsible for the immunological abnormalities seen in active SLE.

KEY WORDS: SLE, IL-15, IL-15R, Lymphocyte, CD25, Bcl-2, IL-2, TNF, ELISA.

Correspondence to: J. S. Smolen, Department of Rheumatology, Internal Medicine III, University of Vienna, AKH, Währinger Gürtel 18–20, A-1090 Vienna, Austria


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
H.-R. Kim, K.-A Hwang, and I. Kang
Dual Roles of IL-15 in Maintaining IL-7R{alpha}lowCCR7 Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
J. Immunol., November 15, 2007; 179(10): 6734 - 6740.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
L. Baranda, H. de la Fuente, E. Layseca-Espinosa, D. Portales-Perez, P. Nino-Moreno, G. Valencia-Pacheco, C. Abud-Mendoza, J. Alcocer-Varela, and R. Gonzalez-Amaro
IL-15 and IL-15R in leucocytes from patients with systemic lupus erythematosus
Rheumatology, December 1, 2005; 44(12): 1507 - 1513.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.