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Rheumatology 2002; 41: 1183-1189
© 2002 British Society for Rheumatology

Paediatric Rheumatology

Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients

W. Thomson, J. H. Barrett, R. Donn, L. Pepper, L. J. Kennedy, W. E. R. Ollier, A. J. S. Silman, British Paediatric Rheumatology Study Group, P. Woo1 and T. Southwood2

Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT
1 Centre for Paediatric and Adolescent Rheumatology, UCMLS, London W1P 6DB and
2 Department of Rheumatology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

Abstract

Objective. To determine the HLA associations with juvenile idiopathic arthritis (JIA) and its subgroups as defined by the International League of Associations for Rheumatology (ILAR) classification criteria.

Methods. Five hundred and twenty-one UK Caucasian JIA patients and 537 UK Caucasian controls were typed for HLA class II alleles. Phenotype and haplotype frequencies were compared between all JIA cases and controls and between the seven ILAR-defined JIA subgroups.

Results. Three haplotypes (DRB1*08-DQA1*0401-DQB1*0402; DRB1*11-DQA1*05-DQB1*03; DRB1*1301-DQA1*01-DQB1*06) were associated with increased risk and one (DRB1*04-DQA1*03-DQB1*03) with decreased risk of JIA. However, in each case the frequencies also varied between JIA subgroups.

Conclusion. This study categorically demonstrates that there are multiple HLA class II associations with JIA. It has also, for the first time, defined these associations in the seven different ILAR subgroups in UK JIA cases. Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients.

KEY WORDS: JIA, HLA.

Notes

Correspondence to: W. Thomson, Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

Contributors to the British Paediatric Rheumatology Study Group: A. Bell, Belfast; A. Craft, Newcastle; J. David, Battle, Reading; J. Griffin, Enfield; A. Hall, Wrexham Park, Slough; M. Hall, Cardiff; A. Herrick, Hope Hospital, Manchester; P. Hollingworth, Bristol; L. Holt, ARC, Manchester; S. Jones, Blackpool; G. Pountain, Huntingdon; C. Ryder, Nuneaton; T. Southwood, Birmingham; I. Stewart, Blackpool; P. Woo, Great Ormond Street and Middlesex Hospitals; S. Wyatt, Leeds; H. Venning, Nottingham.


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