Rheumatology 2002; 41: 1308-1312
© 2002 British Society for Rheumatology
Original Papers |
Outcome of neuropsychiatric systemic lupus erythematosus within a defined Swedish population: increased morbidity but low mortality
Department of Rheumatology and
1 Department of Neurology, University Hospital of Lund, Lund, Sweden
Objective. To investigate the outcome of neuropsychiatric involvement in systemic lupus erythematosus patients (NPSLE) recruited from a defined population.
Methods. All cases of adult SLE diagnosed during 1981–1995 within the Lund-Orup Health Care District were followed prospectively and neuropsychiatric manifestations were recorded. The SLICC/ACR (Systemic Lupus International Collaborating Clinics/American College of Rheumatology) Damage Index, mortality and working incapacity were recorded as measures of outcome.
Results. NPSLE manifestations developed in 38% (44/117) of the patients. A high rate of organ damage (SLICC/ACR Damage Index) was recorded in the NPSLE patients (P<0.001). Compared with patients without neuropsychiatric involvement, NPSLE patients were treated more intensively, with glucocorticoids (P<0.01) and cytostatic drugs (P<0.01). When compared with the normal population in the same area, the NPSLE patients had a higher rate of working incapacity (relative risk 4.0, 95% confidence interval 2.06–6.96), whereas mortality was not increased (standardized mortality rate 1.4, 95% confidence interval 0.5–3.0).
Conclusions. SLE patients with neuropsychiatric involvement have an increased rate of organ damage and a high degree of working incapacity, which illustrates the severity of disease in this subgroup.
KEY WORDS: SLE, SLICC/ACR Damage Index, Damage, Neuropsychiatric, NPSLE, Outcome, Mortality, Working incapacity, Morbidity, Disability.
Correspondence to: A. Jönsen, Department of Rheumatology, University Hospital of Lund, S-221 85 Lund, Sweden.
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