Rheumatology 2002; 41: 142-147
© 2002 British Society for Rheumatology
Original papers |
Relevant change in radiological progression in patients with hip osteoarthritis. I. Determination using predictive validity for total hip arthroplasty
1 René Descartes University, Cochin Hospital, Institut de Rhumatologie, Paris,
2 INSERM U88, St Maurice Hospital, Paris,
3 NEGMA Laboratories, Toussus le Noble,
4 General Hospital, Dijon,
5 Leopold Bellan Hospital, Paris,
6 Rangueil Hospital, Toulouse and
7 Lyon-Sud Hospital, Pierre Bénite, France
Objective. To determine a cut-off point above which a change in joint space width (JSW) could be considered as relevant in patients with hip osteoarthritis (OA) on the basis of predicted need for subsequent total hip arthroplasty (THA).
Methods. A multicentre, prospective, longitudinal, 5-yr follow-up study was performed. A pelvic radiograph was obtained at entry and after 1 and 2 yr. For each film, the narrowest JSW was measured using a 0.1 mm graduated magnifying glass. The absolute and relative differences between baseline and 1 and 2 yr of follow-up were calculated. We determined the cut-off points above which an absolute or relative decrease in JSW between baseline and 1 and 2 yr of follow-up could be considered relevant on the basis of the predicted need for THA during the remaining years of the study. The need for THA was categorized as ‘yes’ or ‘no’. Thereafter, for each observed change in JSW (0.1 per 0.1 mm or 1% per 1%), the sensitivity and specificity for subsequent THA were calculated. The choice of cut-off was based on maximal sensitivity and specificity, using the graphic representation of correct classification probabilities. In this way it was possible to obtain the best measured JSW threshold with maximal true positive and minimal false positive results.
Results. A total of 423 and 385 patients met the criteria for analysis using the decrease in JSW between baseline and 1 and 2 yr respectively. The best cut-off points were absolute decreases in JSW of 0.2 and 0.4 mm and relative decreases in JSW of 15 and 20% after 1 and 2 yr respectively, with corresponding ranges of sensitivity and specificity of 68–75 and 67–78%.
Conclusion. This work determined the cut-off above which a change in JSW could be considered clinically relevant in patients with hip OA, on the basis of predicted subsequent need for THA. For validation, similar studies should be conducted in other countries with different health-care systems.
KEY WORDS: Relevant change, Predictive validity, Total hip arthroplasty, Hip osteoarthritis, Joint space width, Outcome measure.
Correspondence to: M. Dougados, Institut de Rhumatologie, Cochin Hospital, 27 rue du Faubourg St Jacques, 75014 Paris cedex 14, France.
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