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Rheumatology 2002; 41: 216-222
© 2002 British Society for Rheumatology

Grand Rounds in Rheumatology

Miller Fisher syndrome in adult onset Still's disease: case report and review of the literature of other neurological manifestations

S. S. Desai, E. Allen and A. Deodhar

Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, CR 119, Portland, OR 97201, USA

Abstract

Adult-onset Still's disease (AOSD) is a multi-system inflammatory disorder characterized by high spiking fevers, evanescent salmon-coloured rash, arthralgias or arthritis, hepatosplenomegaly, lymphadenopathy and sore throat. There is no specific test or combination of tests that can establish the diagnosis of AOSD and patients may present with other systemic involvement including neurological manifestations in 7–12% of cases. We present a complex case of a patient with AOSD who developed the Miller-Fisher variant of Guillain–Barré syndrome. This immunological disorder of the nervous system has not been described in association with AOSD before. We also review the literature on other neurological manifestations in AOSD. AOSD mimics different disease processes and its multi-system manifestations may complicate the picture further.

KEY WORDS: Miller Fisher syndrome, Still's disease, Guillain–Barré syndrome, Neurological manifestations, Adult Still's disease, gangliosides.

Notes

Correspondence to: S. S. Desai.


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