Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Li, T. F.
Right arrow Articles by Konttinen, Y. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, T. F.
Right arrow Articles by Konttinen, Y. T.
Related Collections
Right arrow Soft Tissue Rheumatism
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2002; 41: 319-323
© 2002 British Society for Rheumatology

Original Papers

Dendritic cells in rheumatoid synovial membrane after total removal of the hyaline articular cartilage

T. F. Li1,2, J. Mandelin3, M. Hukkanen2, J. Lassus1, J. Sandelin2, S. Santavirta1, I. Virtanen3 and Y. T. Konttinen2,4,5,

1 Department of Orthopaedics and Traumatology, Helsinki University Hospital,
2 ORTON Research Institute, Orthopaedic Hospital of Invalid Foundation, Helsinki,
3 Department of Anatomy, Biomedicum, University of Helsinki,
4 Department of Medicine/Invärtes Medicine, Helsinki University Hospital and
5 Department of Oral Medicine, Institute of Dentistry, University of Helsinki, Finland

Objective. To investigate the effect of total removal of the hyaline articular cartilage on dendritic cells in synovial membrane in rheumatoid arthritis (RA) or ankylosing spondylitis (AS).

Patients and methods. Immunohistochemical staining for two dendritic cell markers, CD35 and RFD1, was carried out on synovial membrane specimens from arthritis patients undergoing primary (n=10) or revision (n=8) total hip replacement (THR). The results are expressed as the number (mean±standard deviation) of positive cells per 1000 total cells.

Results. CD35-(112±9) and RFD1-(27±5) positive cells were found in all primary RA synovial membrane, while only two out of eight synovial membrane samples from revision THR contained CD35-positive follicular dendritic cells (nine and 12 cells), and no revision samples contained any RFD1-positive interdigitating dendritic cells.

Conclusion. Removal of the hyaline articular cartilage reduces the infiltration and functional differentiation of dendritic cells in synovial membrane. Our findings suggest that the antigen driving chronic arthritis/synovitis is contained in the hyaline articular cartilage.

KEY WORDS: Dendritic cells, Rheumatoid arthritis, Synovial membrane, Hyaline articular cartilage, Total hip replacement.

Correspondence to: Y. T. Konttinen, Biomedicum Helsinki, PO Box 700 (Haartmaninkatu 8), 00029-HUS, Helsinki, Finland.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.