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Rheumatology 2002; 41: 462-465
© 2002 British Society for Rheumatology

Paediatric Rheumatology

Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis

Paediatric Rheumatology/Series Editor: P. Woo

E. Zeggini, W. Thomson, A. Alansari, W. Ollier and R. Donn The British Paediatric Rheumatology Study Group*

ARC/EU, Stopford Building, Oxford Road, Manchester M13 9PT, UK

Abstract

Objectives. Juvenile idiopathic arthritis (JIA) is a complex polygenic disorder. The encouraging outcome of anti-tumour necrosis factor (TNF) treatment, as well as serological studies, has implicated TNF and its receptors (TNFRI and TNFRII, or TNFRSF1B) in the pathogenesis of JIA. The purpose of this study was to investigate the exon 6 TNFRII single nucleotide polymorphism (SNP) in a well-defined UK cohort of JIA patients, using case–control association analysis.

Methods. A total of 435 patients, spanning seven JIA subgroups, and 261 healthy individuals were screened for the polymorphism using the polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) method.

Results. No significant differences were observed between the SNP allelic or genotypic frequencies of patients and controls, or between JIA subgroups.

Conclusions. This TNFRII exon 6 SNP does not seem to be associated with susceptibility to JIA.

KEY WORDS: Complex genetic disease, Juvenile idiopathic arthritis, Single nucleotide polymorphism, Tumour necrosis factor receptor II.

Notes

Correspondence to: E. Zeggini.

* The contributors to the British Paediatric Rheumatology Study Group are listed in the Acknowledgements.


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