Skip Navigation


Rheumatology Advance Access originally published online on June 16, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
42/11/1380    most recent
keg383v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Ferreirós-Vidal, I.
Right arrow Articles by Gonzalez, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ferreirós-Vidal, I.
Right arrow Articles by Gonzalez, A.
Related Collections
Right arrow Immunogenetics
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2003; 42: 1380-1382
© 2003 British Society for Rheumatology

CARD15/NOD2 analysis in rheumatoid arthritis susceptibility

I. Ferreirós-Vidal, F. Barros1, J. L. Pablos2, A. Carracedo1, J. J. Gómez-Reino and A. Gonzalez

Research Laboratory 2 and the Rheumatology Unit, Hospital Clinico Universitario de Santiago, 1Molecular Medicine Unit-INGO-Universidad de Santiago de Compostela and 2Rheumatology Unit, Hospital 12 de Octubre, Madrid, Spain.

Correspondence to: A. Gonzalez, Laboratorio de Investigacion 2, Hospital Clinico Universitario de Santiago, 15706-Santiago de Compostela, Spain. E-mail: gon2906{at}globalum.com

Objective. To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA).

Methods. The frequencies of the three commonest mutations of CARD15/NOD2 predisposing to CD (2104C > T, 2722G>C and 3020insC) were determined in 210 RA patients and 227 controls.

Results. Allelic frequencies of the CARD15/NOD2 mutations in RA patients (2104C>T, 2.8%; 2722G>C, 0.9%; and 3020insC, 2.4%) did not differ significantly from the controls (2104C>T, 5.3%; 2722G>C, 0.7%; and 3020insC, 1.1%).

Conclusion. There was no evidence of association between the commonest CD CARD15/NOD2 mutations and RA susceptibility.

KEY WORDS: Rheumatoid arthritis, Crohn's disease, Genetic predisposition to disease, Autoimmune diseases.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.