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Rheumatology Advance Access originally published online on July 16, 2003
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Rheumatology 2003; 42: 1501-1507
© 2003 British Society for Rheumatology

Independent association of HLA-DR and FC{gamma} receptor polymorphisms in Korean patients with systemic lupus erythematosus

H. S. Lee, Y. H. Chung1, T. G. Kim2, T. H. Kim, J. B. Jun, S. Jung, S. C. Bae and D. H. Yoo

Division of Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, 1Department of Microbiology, Hanyang University Medical College, Seoul and 2Department of Microbiology and Immunology, Catholic University College of Medicine, Seoul, Korea.

Correspondence to: D. H. Yoo, The Hospital for Rheumatic Diseases, Hanyang University, Seoul, 133–792, Korea. E-mail: dhyoo{at}hanyang.ac.kr

Objectives. To determine the distribution of HLA-DR type and Fc{gamma}RIIa/IIIa polymorphisms, and to analyse the combined effects of these genes for susceptibility in Korean systemic lupus erythematosus (SLE) patients.

Methods. A total of 299 SLE patients meeting 1982 ACR criteria and 144 Korean disease-free controls were enrolled. Genotyping for the Fc{gamma}RIIa 131 R/H and Fc{gamma}RIIIa 176 F/V was performed by polymerase chain reaction (PCR) of genomic DNA using allele-specific primers. HLA-DRB1 typing was performed by the PCR-SSOP method.

Results. There was significant skewing in the distribution of the three Fc{gamma}RIIa genotypes between the SLE patients and the controls [P = 0.002 for R/R131 vs R/H131 and H/H131, relative risk (RR) 2.6 (95% CI 1.3–5.2)], but not in Fc{gamma}RIIIa genotypes. HLA-DRB1*15 allele was significantly more prevalent among SLE patients than the control population [P < 0.02, RR = 1.7 (1.1–2.6)]. HLA-DRB1 genotypes or allele frequencies of the SLE patients with nephritis did not differ significantly from those of the SLE patients without nephritis. We analysed the combined effects of the two candidate genes on SLE susceptibility. HLA-DRB1*15 allele was a significant predictor of SLE in individuals who were not homozygous for Fc{gamma}RIIa-R/R131 [RR = 2.1 (1.2–3.7), P < 0.008], and the Fc{gamma}RIIa-R/R131 genotype vice versa [RR = 5.3 (1.9–15.4), P < 0.001]. However, an additive or synergistic effect of both susceptible genes on relative risk for SLE was not evident.

Conclusions. Our results suggest that Fc{gamma}RIIa-R/R131 homozygote and HLA-DRB1*15 allele are independent risk factors in Korean SLE patients without additive or synergistic effects.

KEY WORDS: SLE, HLA-DR type, Fc{gamma}RIIa and IIIa polymorphism.


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C-H Hong, J-S Lee, H-S Lee, S-C Bae, and D-H Yoo
The association between FcgRIIIB polymorphisms and systemic lupus erythematosus in Korea
Lupus, May 1, 2005; 14(5): 346 - 350.
[Abstract] [PDF]


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