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Rheumatology 2003; 42: 214-222
© 2003 British Society for Rheumatology

Review

Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus

K. Yasutomo

Department of Immunology and Parasitology, School of Medicine, The University of Tokushima, 3–18–15 Kuramoto, Tokushima 770-8503, Japan. E-mail: yasumoto{at}basic.med.tokushima-u.ac.jp

Systemic lupus erythematosus (SLE) is one of the autoimmune diseases extensively studied by immunologists and physicians. The main focus regarding SLE pathophysiology has been placed on abnormal cell surface receptor function on lymphocytes. However, recent studies have revealed that defective clearance of apoptotic cells causes self-antigen accumulation, which could trigger the activation of autoreactive lymphocytes. Thus, here we review current findings about the association of the defective clearance of autoantigens and SLE, focusing on mutations in the DNase I locus and their relationship to SLE.


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