Skip Navigation


Rheumatology Advance Access originally published online on February 28, 2003
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
42/3/413    most recent
keg116v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Nordborg, E.
Right arrow Articles by Nordborg, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nordborg, E.
Right arrow Articles by Nordborg, C.
Related Collections
Right arrow Vasculitis
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Rheumatology 2003; 42: 413-421
© 2003 British Society for Rheumatology

Review

Giant cell arteritis: epidemiological clues to its pathogenesis and an update on its treatment

E. Nordborg and C. Nordborg

Departments of Rheumatology, Sahlgrenska University Hospital, SE-413 45, Göteborg, Sweden

Giant cell arteritis (GCA) is a chronic systemic vasculitis with a marked female predominance and restriction to old age. The disease process distinctly targets large and medium sized arteries, preferentially the aorta and its extracranial branches. Morphological observations indicate that the age and sex distribution of GCA is related to the occurrence of degenerative changes in the arterial wall. GCA is not a truly infectious vasculitis. However, an infection might be a triggering factor. Different centres report an increase in GCA incidence, but annual fluctuations have not been shown to be statistically significant. However, significant seasonal variations have been observed by several groups. The mortality is not increased in adequately treated patients. Although, alternative steroid-sparing agents have been proposed, corticosteroids are still the first treatment choice.

Correspondence to: E. Nordborg. E-mail: nordborg{at}swipnet.se


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Rheumatology (Oxford)Home page
T. A. Bley, M. Markl, M. Schelp, M. Uhl, A. Frydrychowicz, P. Vaith, H.-H. Peter, M. Langer, and K. Warnatz
Mural inflammatory hyperenhancement in MRI of giant cell (temporal) arteritis resolves under corticosteroid treatment
Rheumatology, January 1, 2008; 47(1): 65 - 67.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. H. Shmerling
An 81-year-old woman with temporal arteritis.
JAMA, June 7, 2006; 295(21): 2525 - 2534.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
K Larsson, D Mellstrom, C Nordborg, A Oden, and E Nordborg
Early menopause, low body mass index, and smoking are independent risk factors for developing giant cell arteritis
Ann Rheum Dis, April 1, 2006; 65(4): 529 - 532.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
J. Lenton, R. Donnelly, and J.R. Nash
Does temporal artery biopsy influence the management of temporal arteritis?
QJM, January 1, 2006; 99(1): 33 - 36.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. Shepherd and M. J.H. Nicklin
Elastic-Vessel Arteritis in Interleukin-1 Receptor Antagonist-Deficient Mice Involves Effector Th1 Cells and Requires Interleukin-1 Receptor
Circulation, June 14, 2005; 111(23): 3135 - 3140.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
W. M. Chan, D. T. L. Liu, A. Y. K. Chan, C. H. Y. Lai, P. C. L. Choi, and D. S. C. Lam
ANCA-associated giant cell arteritis presenting with mononeuritis multiplex and central retinal artery occlusion: a case report
Rheumatology, April 1, 2004; 43(4): 529 - 531.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.