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Rheumatology Advance Access originally published online on February 28, 2003
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Rheumatology 2003; 42: 758-762
© 2003 British Society for Rheumatology

Cardiovascular risk in systemic lupus erythematosus—evidence of increased oxidative stress and dyslipidaemia

S. L. Nuttall1,, S. Heaton2, M. K. Piper2, U. Martin1 and C. Gordon2

Departments of
1 Clinical Pharmacology and
2 Rheumatology, University of Birmingham, Birmingham, UK

Objectives. Systemic lupus erythematosus (SLE) is associated with severe and premature cardiovascular disease, which is not explained by traditional risk factors alone. This study aimed to investigate markers of oxidative stress, lipid metabolism and inflammation as potential cardiovascular risk factors in women with SLE.

Methods. Venous blood samples were taken from 53 female Caucasian patients with SLE and from healthy age- and sex-matched controls. Samples were analysed for markers of oxidative stress, lipid metabolism [including low-density lipoprotein (LDL) subfraction profile] and C-reactive protein (CRP).

Results. Female SLE patients had an atherogenic lipid profile characterized by raised total cholesterol and triglycerides, and the presence of small, dense LDL subfractions compared with healthy controls. These changes were associated with increased oxidative damage and a moderately raised CRP.

Conclusions. The results provide evidence for free radical and inflammatory activity in SLE and suggest potential targets to reduce the risk of cardiovascular disease in these patients.

KEY WORDS: Lupus, Oxidative stress, LDL subfractions, Cardiovascular risk.

Correspondence to: S. L. Nuttall, Clinical Investigation Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK. E-mail: s.nuttall{at}bham.ac.uk


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