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Rheumatology Advance Access originally published online on April 30, 2003
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Rheumatology 2003; 42: 1089-1092
© 2003 British Society for Rheumatology

Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C

J. Martínez-Borra, S. González2, J. Santos-Juanes1, J. Sánchez del Río1, J. C. Torre-Alonso3, A. López-Vázquez, M. A. Blanco-Geláz and C. López-Larrea

Departments of Immunology and
1 Dermatology, Hospital Central de Asturias,
2 Department of Functional Biology, University of Oviedo and
3 Hospital Monte Naranco, Oviedo, Spain

Objective. To map the locus for susceptibility to psoriasis in patients with psoriatic arthritis.

Methods. Seventy-four patients with psoriatic arthritis and 95 patients with psoriasis vulgaris were included in this study. Polymorphic genes and microsatellite markers centromeric (C1_2_5) and telomeric (C1_4_4, OTF3, HCR and the corneodesmosin gene) to HLA-C were studied in an association analysis. Typing was also performed on a control population of 104 matched donors.

Results. The allele Cw*0602 was associated both with psoriasis [49 vs 21%, Pc<0.0003; odds ratio (OR)=3.6, aetiological factor (AF)=0.72] and with psoriatic arthritis (62 vs 21%, Pc<0.000001; OR=6.1, AF=0.83). In psoriatic patients a susceptibility region telomeric to HLA-C that includes C1_4_4 (56 vs 22%, Pc<0.0002; OR=4.39, AF=0.77), OTF3 (85 vs 60%, Pc<0.0002; OR=3.7, AF=0.73) and HCR (63 vs 26%, Pc<0.00001; OR=3.8, AF=0.74) was observed. In psoriatic arthritis patients the susceptibility region was delimited by HLA-C and C1_4_4 (384 allele, 56 vs 22%, Pc<0.0002; OR=4.37, AF=0.77).

Conclusions. Comparing the susceptibility regions associated with the two diseases, an overlapping interval of 100 kb between HLA-C and OTF3, which might contain the psoriasis gene, can be defined.

KEY WORDS: Psoriatic arthritis, Psoriasis vulgaris, HLA-C, C1_4_4.

Correspondence to: C. López-Larrea, Department of Immunology, Hospital Central de Asturias, 33006 Oviedo, Spain. E-mail: inmuno{at}hca.es


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